Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC4617966 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Sun Yujia Y Nien Chung-Yi CY Chen Kai K Liu Hsiao-Yun HY Johnston Jeff J Zeitlinger Julia J Rushlow Christine C
Genome research 20150902 11
The Drosophila genome activator Vielfaltig (Vfl), also known as Zelda (Zld), is thought to prime enhancers for activation by patterning transcription factors (TFs). Such priming is accompanied by increased chromatin accessibility, but the mechanisms by which this occurs are poorly understood. Here, we analyze the effect of Zld on genome-wide nucleosome occupancy and binding of the patterning TF Dorsal (Dl). Our results show that early enhancers are characterized by an intrinsically high nucleoso ...[more]