Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures.

ABSTRACT:

Background

Statin therapy influences not only low-density lipoprotein (LDL) cholesterol levels but also LDL-related biomarkers, including non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B, total number of LDL particles, and mean LDL particle size. Recent studies have identified many genetic loci influencing circulating lipid levels and statin-induced LDL cholesterol reduction. However, it is unknown how these genetic variants influence statin-induced changes in LDL subfractions and non-HDL-C.

Methods and results

One hundred sixty candidate single-nucleotide polymorphisms for effects on circulating lipid levels or statin-induced LDL-cholesterol lowering were tested for association with response of LDL subfractions and non-HDL-C to rosuvastatin or placebo

SUBMITTER: Chu AY 

PROVIDER: S-EPMC4618030 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature