Neurocognitive Changes after Sustained Ketamine Administration in Children with Chronic Pain.

ABSTRACT:

Introduction

Ketamine has received attention recently as an agent for chronic pain. There are concerns, however, regarding the neurocognitive changes patients might experience after ketamine exposure.

Methods

This prospective, uncontrolled study describes the neurocognitive functioning of 11 children with chronic pain before and after 2 weeks of daily oral ketamine exposure. Neurocognitive assessment was performed at baseline, Week 2, and Week 14. We hypothesized that there would be declines in neurocognitive scores at either Week 2 or Week 14.

Results

No decline in neurocognitive function was detected in the children investigated. Mean scores for tests measuring executive function and memory were improved at Weeks 2 and 14 compared to baseline.

Discussion

This

SUBMITTER: Bredlau AL 

PROVIDER: S-EPMC4618408 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature