The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm.

ABSTRACT:

Background

In the visual system of most binocular vertebrates, the axons of retinal ganglion cells (RGCs) diverge at the diencephalic midline and extend to targets on both ipsi- and contralateral sides of the brain. While a molecular mechanism explaining ipsilateral guidance decisions has been characterized, less is known of how RGC axons cross the midline.

Results

Here, we took advantage of the zebrafish, in which all RGC axons project contralaterally at the optic chiasm, to characterize Islr2 as an RGC receptor required for complete retinal axon midline crossing. We used a systematic extracellular protein-protein interaction screening assay to identify two Vasorin paralogs, Vasna and Vasnb, as specific Islr2 ligands. Antibodies against Vasna and Vasnb reveal cellular popul

SUBMITTER: Panza P 

PROVIDER: S-EPMC4618557 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature