Genetic profiles of cervical tumors by high-throughput sequencing for personalized medical care.

ABSTRACT: Cancer treatment is facing major evolution since the advent of targeted therapies. Building genetic profiles could predict sensitivity or resistance to these therapies and highlight disease-specific abnormalities, supporting personalized patient care. In the context of biomedical research and clinical diagnosis, our laboratory has developed an oncogenic panel comprised of 226 genes and a dedicated bioinformatic pipeline to explore somatic mutations in cervical carcinomas, using high-throughput sequencing. Twenty-nine tumors were sequenced for exons within 226 genes. The automated pipeline used includes a database and a filtration system dedicated to identifying mutations of interest and excluding false positive and germline mutations. One-hundred and seventy-six total mutational events wer

SUBMITTER: Muller E 

PROVIDER: S-EPMC4618619 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature