Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans.

ABSTRACT:

Background

Adipose tissues play important role in the pathophysiology of obesity-related diseases including type 2 diabetes (T2D). To describe gene expression patterns and functional pathways in obesity-related T2D, we performed global transcript profiling of omental adipose tissue (OAT) in morbidly obese individuals with or without T2D.

Methods

Twenty morbidly obese (mean BMI: about 54 kg/m²) subjects were studied, including 14 morbidly obese individuals with T2D (cases) and 6 morbidly obese individuals without T2D (reference group). Gene expression profiling was performed using the Affymetrix U133 Plus 2.0 human genome expression array. Analysis of covariance was performed to identify differentially expressed genes (DEGs). Bioinformatics tools including PANTHER

SUBMITTER: Doumatey AP 

PROVIDER: S-EPMC4618674 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature