Ontology highlight
ABSTRACT:
SUBMITTER: Geng H
PROVIDER: S-EPMC4618684 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Cancer cell 20150301 3
Studying 830 pre-B ALL cases from four clinical trials, we found that human ALL can be divided into two fundamentally distinct subtypes based on pre-BCR function. While absent in the majority of ALL cases, tonic pre-BCR signaling was found in 112 cases (13.5%). In these cases, tonic pre-BCR signaling induced activation of BCL6, which in turn increased pre-BCR signaling output at the transcriptional level. Interestingly, inhibition of pre-BCR-related tyrosine kinases reduced constitutive BCL6 exp ...[more]