Ontology highlight
ABSTRACT:
SUBMITTER: Clarke RL
PROVIDER: S-EPMC4618836 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Clarke Raedun L RL Robitaille Aaron M AM Moon Randall T RT Keller Gordon G
Stem cell reports 20150801 2
The in vitro derivation of hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) is complicated by the existence of multiple overlapping embryonic blood cell programs called primitive, erythromyeloid progenitor (EMP), and definitive. As HSCs are only generated during the definitive stage of hematopoiesis, deciphering the regulatory pathways that control the emergence of this program and identifying markers that distinguish it from the other programs are essential. To identify defini ...[more]