Possible changes in the transmissibility of trachoma following MDA and transmission reduction: implications for the GET2020 goals.

ABSTRACT:

Background

The role of mass drug administration (MDA) and the implementation of transmission reduction measures are essential to successfully control and eliminate a wide range of NTDs, including the ocular disease trachoma. Immunity to trachoma infection acts by reducing the duration of an individual's infectious period and by reducing their infectivity with each successive infection.

Methods

In this study, we use a model of trachoma infection, which includes population immunity, to explore the impact of treatment and transmission reduction measures on trachoma prevalence. Specifically, we investigate the possibility of increasing transmissibility of trachoma arising as MDA and transmission reduction measures are scaled up in endemic settings.

Results

We demonstrate

SUBMITTER: Gambhir M 

PROVIDER: S-EPMC4618927 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature