Ontology highlight
ABSTRACT:
SUBMITTER: Gupta PK
PROVIDER: S-EPMC4618999 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
PLoS pathogens 20151020 10
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells specific for HCV or HIV express high levels of CD39, but those specific for EBV and CMV do not. CD39 expressed by CD8+ T cells in chronic infection is en ...[more]