Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells.

ABSTRACT:

Background

Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property.

Methods

In this study, we determined the efficacy of PC as an anti-neoplastic agent in vitro on a series of breast cancer cell lines. We studied effects of PC in inducing DNA damage and apoptosis through western blot and qPCR. Also, anti-metastatic and anti-angiogenic properties were studied by classic wound healing and vasculogenic mimicry assays.

Results

We found that triple negative MDA-MB-231 cells were most sensitive to PC (IC50 : 5.98 ± 0.95 μM) as compared to other

SUBMITTER: Ravi M 

PROVIDER: S-EPMC4619068 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature