Allergens Induce the Release of Lactoferrin by Neutrophils from Asthmatic Patients.

ABSTRACT:

Background

Despite the evidence that Lactoferrin (Lf) is involved in allergic asthma processes, it is unknown whether neutrophils can be one of the main cellular sources of this key inflammatory mediator directly in response of an IgE mediated stimulus. The present study was undertaken to analyze this question.

Methods

Neutrophils from healthy subjects (n = 34) and neutrophils from allergic asthmatic patients (n = 102) were challenged in vitro with specific allergens to which the patients were sensitized, PAF, or agonist mAbs against IgE-receptors, and the levels of Lf were measured in the culture supernatant. The levels of serum IgE together with the severity of symptoms were also analyzed.

Results

Lf was released into the culture supernatant of neutrophils from alle

SUBMITTER: Fernandez-Delgado L 

PROVIDER: S-EPMC4619071 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature