Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension.

ABSTRACT:

Rationale

Chronic inflammation is a major contributor to the progressive pathology of hypertension, and T-cell activation is required for the genesis of hypertension. However, the precise role of myeloid cells in this process is unclear.

Objective

To characterize and understand the role of peripheral myeloid cells in the development of hypertension.

Methods and results

We examined myeloid cells in the periphery of hypertensive mice and found that increased numbers of CD11b(+)Gr1(+) myeloid cells in blood and the spleen are a characteristic of 3 murine models of experimental hypertension (angiotensin II, L-NG-nitroarginine methyl ester, and high salt). These cells express surface markers and transcription factors associated with immaturity and immunosuppression. Also,

SUBMITTER: Shah KH 

PROVIDER: S-EPMC4619122 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature