Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups.

ABSTRACT:

Purpose

Prognostic models have been proposed to predict survival for non-small-cell lung cancer (NSCLC). It is important to evaluate whether these models perform better than performance status (PS) alone in stage- and age-specific subgroups.

Patients and methods

The validation cohort included 2060 stage I and 1611 stage IV NSCLC patients from 23CALGB studies. For stage I, Blanchon (B), Chansky (C) and Gail (G) models were evaluated along with the PS only model. For stage IV, Blanchon (B) and Mandrekar (M) models were compared with the PS only model. The c-index was used to assess the concordance between survival and risk scores. The c-index difference (c-difference) and the integrated discrimination improvement (IDI) were used to determine the improvement of these models ove

SUBMITTER: Wang X 

PROVIDER: S-EPMC4619143 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature