Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.

ABSTRACT:

Rationale

Local plaque macrophage proliferation and monocyte production in hematopoietic organs promote progression of atherosclerosis. Therefore, noninvasive imaging of proliferation could serve as a biomarker and monitor therapeutic intervention.

Objective

To explore (18)F-FLT positron emission tomography-computed tomography imaging of cell proliferation in atherosclerosis.

Methods and results

(18)F-FLT positron emission tomography-computed tomography was performed in mice, rabbits, and humans with atherosclerosis. In apolipoprotein E knock out mice, increased (18)F-FLT signal was observed in atherosclerotic lesions, spleen, and bone marrow (standardized uptake values wild-type versus apolipoprotein E knock out mice, 0.05 ± 0.01 versus 0.17 ± 0.01, P<0.05 in aorta;

SUBMITTER: Ye YX 

PROVIDER: S-EPMC4619168 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature