Histology-based Classification Predicts Pattern of Recurrence and Improves Risk Stratification in Primary Retroperitoneal Sarcoma.

ABSTRACT:

Objective

To determine the prognostic significance of histologic type/subtype in a large series of patients with primary resected retroperitoneal sarcoma.

Background

The histologic diversity and rarity of retroperitoneal sarcoma has hampered the ability to predict patient outcome.

Methods

From a single-institution, prospective database, 675 patients treated surgically for primary, nonmetastatic retroperitoneal sarcoma during 1982 to 2010 were identified and histologic type/subtype was reviewed. Clinicopathologic variables were analyzed for association with disease-specific death (DSD), local recurrence (LR), and distant recurrence (DR).

Results

Median follow-up for survivors was 7.5 years. The predominant histologies were well-differentiated liposarcoma, dediff

SUBMITTER: Tan MC 

PROVIDER: S-EPMC4619189 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature