Genome-wide identification of copy number variations between two chicken lines that differ in genetic resistance to Marek's disease.

ABSTRACT:

Background

Copy number variation (CNV) is a major source of genome polymorphism that directly contributes to phenotypic variation such as resistance to infectious diseases. Lines 63 and 72 are two highly inbred experimental chicken lines that differ greatly in susceptibility to Marek's disease (MD), and have been used extensively in efforts to identify the genetic and molecular basis for genetic resistance to MD. Using next generation sequencing, we present a genome-wide assessment of CNVs that are potentially associated with genetic resistance to MD.

Methods

Three chickens randomly selected from each line were sequenced to an average depth of 20×. Two popular software, CNVnator and Pindel, were used to call genomic CNVs separately. The results were combined to obtain a unio

SUBMITTER: Yan Y 

PROVIDER: S-EPMC4619206 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature