A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.

ABSTRACT:

Background

Fat infiltration of the liver, muscle and pancreas is associated with insulin resistance and risk of diabetes. Weight loss reduces ectopic fat deposition and risk of diabetes, but is difficult to sustain to due to compensatory increases in appetite. Fermentable carbohydrates have been shown to decrease appetite and food intake, and promote weight loss in overweight subjects. In animal studies, fermentable carbohydrate reduces ectopic fat independent of weight loss. We aimed to investigate the effect of the fermentable carbohydrate inulin on weight maintenance, appetite and ectopic fat in subjects with prediabetes.

Methods

Forty-four subjects with prediabetes were randomized to 18 weeks' inulin or cellulose supplementation. During weeks 1-9 (weight loss phase) all

SUBMITTER: Guess ND 

PROVIDER: S-EPMC4619305 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature