Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.

ABSTRACT:

Background

To examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal vulnerability to ischemic damage, we used the 4-vessel occlusion (4-VO) model of transient global ischemia in rats. 4-VO in rats causes a selective death of pyramidal neurons in the hippocampal CA1 region, leaving neurons of the CA3 region relatively spared. We wondered whether changes in the expression of individual mGlu receptor subtypes selectively occur in the vulnerable CA1 region during the development of ischemic damage, and whether post-ischemic treatment with drugs targeting the selected receptor(s) affords neuroprotection.

Results

We found that 4-VO caused significantly reduction in the transcript of mGlu2 receptors in the CA1 region at times that p

SUBMITTER: Motolese M 

PROVIDER: S-EPMC4619332 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature