Design and optimization of peptide nanoparticles.

ABSTRACT:

Background

Various supra-molecular structures form by self-assembly of proteins in a symmetric fashion. Examples of such structures are viruses, some bacterial micro-compartments and eukaryotic vaults. Peptide/protein-based nanoparticles are emerging in synthetic biology for a variety of biomedical applications, mainly as drug targeting and delivery systems or as vaccines. Our self-assembling peptide nanoparticles (SAPNs) are formed by a single peptide chain that consists of two helical coiled-coil segments connected by a short linker region. One helix is forming a pentameric coiled coil while the other is forming a trimeric coiled coil.

Results

Here, we were studying in vitro and in silico the effect of the chain length and of point mutations near the linker region between

SUBMITTER: Doll TA 

PROVIDER: S-EPMC4619341 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature