Intracellular Information Processing through Encoding and Decoding of Dynamic Signaling Features.

ABSTRACT: Cell signaling dynamics and transcriptional regulatory activities are variable within specific cell types responding to an identical stimulus. In addition to studying the network interactions, there is much interest in utilizing single cell scale data to elucidate the non-random aspects of the variability involved in cellular decision making. Previous studies have considered the information transfer between the signaling and transcriptional domains based on an instantaneous relationship between the molecular activities. These studies predict a limited binary on/off encoding mechanism which underestimates the complexity of biological information processing, and hence the utility of single cell resolution data. Here we pursue a novel strategy that reformulates the information transfer proble

SUBMITTER: Makadia HK 

PROVIDER: S-EPMC4619640 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature