Predicting Abdominal Aortic Aneurysm Target Genes by Level-2 Protein-Protein Interaction.

ABSTRACT: Abdominal aortic aneurysm (AAA) is frequently lethal and has no effective pharmaceutical treatment, posing a great threat to human health. Previous bioinformatics studies of the mechanisms underlying AAA relied largely on the detection of direct protein-protein interactions (level-1 PPI) between the products of reported AAA-related genes. Thus, some proteins not suspected to be directly linked to previously reported genes of pivotal importance to AAA might have been missed. In this study, we constructed an indirect protein-protein interaction (level-2 PPI) network based on common interacting proteins encoded by known AAA-related genes and successfully predicted previously unreported AAA-related genes using this network. We used four methods to test and verify the performance of this level-

SUBMITTER: Zhang K 

PROVIDER: S-EPMC4619739 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature