Configurational Statistics of Magnetic Bead Detection with Magnetoresistive Sensors.

ABSTRACT: Magnetic biosensors detect magnetic beads that, mediated by a target, have bound to a functionalized area. This area is often larger than the area of the sensor. Both the sign and magnitude of the average magnetic field experienced by the sensor from a magnetic bead depends on the location of the bead relative to the sensor. Consequently, the signal from multiple beads also depends on their locations. Thus, a given coverage of the functionalized area with magnetic beads does not result in a given detector response, except on the average, over many realizations of the same coverage. We present a systematic theoretical analysis of how this location-dependence affects the sensor response. The analysis is done for beads magnetized by a homogeneous in-plane magnetic field. We determine the expe

SUBMITTER: Henriksen AD 

PROVIDER: S-EPMC4619777 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature