Critical Roles of the Direct GABAergic Pallido-cortical Pathway in Controlling Absence Seizures.

ABSTRACT: The basal ganglia (BG), serving as an intermediate bridge between the cerebral cortex and thalamus, are believed to play crucial roles in controlling absence seizure activities generated by the pathological corticothalamic system. Inspired by recent experiments, here we systematically investigate the contribution of a novel identified GABAergic pallido-cortical pathway, projecting from the globus pallidus externa (GPe) in the BG to the cerebral cortex, to the control of absence seizures. By computational modelling, we find that both increasing the activation of GPe neurons and enhancing the coupling strength of the inhibitory pallido-cortical pathway can suppress the bilaterally synchronous 2-4 Hz spike and wave discharges (SWDs) during absence seizures. Appropriate tuning of several GPe-r

SUBMITTER: Chen M 

PROVIDER: S-EPMC4619822 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature