Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer.

ABSTRACT:

Background

The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC).

Methods

The expression profiles of cancer cells in 152 patients with stage I-III CRC were examined using microarray analysis. High expression in CRC cells, especially in patients with distant recurrences, was a prerequisite to select candidate genes. Thus, we identified seventeen candidate genes, and selected Traf2- and Nck-interacting kinase (TNIK), which was known to be associated with progression in CRC through Wnt signaling pathways. We analyzed the protein expression of TNIK using immunohistochemistry (IHC) and investigated the relationshi

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC4619995 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature