Risk stratification in patients with pulmonary hypertension undergoing transcatheter aortic valve replacement.

ABSTRACT:

Objective

Pulmonary hypertension (PH) is associated with increased mortality after surgical or transcatheter aortic valve replacement (TAVR) for aortic stenosis (AS), and when the pulmonary artery pressure is particularly elevated, there may be questions about the clinical benefit of TAVR. We aimed to identify clinical and haemodynamic factors associated with increased mortality after TAVR among those with moderate/severe PH.

Methods

Among patients with symptomatic AS at high or prohibitive surgical risk receiving TAVR in the Placement of Aortic Transcatheter Valves (PARTNER) I randomised trial or registry, 2180 patients with an invasive measurement of mean pulmonary artery pressure (mPAP) recorded were included, and moderate/severe PH was defined as an mPAP ≥35 mm Hg.

Re

SUBMITTER: Lindman BR 

PROVIDER: S-EPMC4620051 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature