A Longitudinal Study of BDNF Promoter Methylation and Depression in Breast Cancer.

ABSTRACT:

Objective

Brain-derived neurotrophic factor (BDNF) is investigated in depression related to medical disorders and its secretion is influenced by epigenetic factors. We investigated the association between BDNF promoter methylation and depression following mastectomy for breast cancer.

Methods

In total, 309 patients with breast cancer were evaluated 1 week after mastectomy, and 244 (79%) were followed up 1 year later. Depression was diagnosed (major or minor depressive disorder) according to DSM-IV criteria and depression severity was estimated by Montgomery-Asberg Depression Rating Scale (MADRS). We assessed BDNF promoter methylation using leukocyte DNA. The effects of BDNF methylation on depression diagnosis and severity were investigated using multivariate logistic and lin

SUBMITTER: Kang HJ 

PROVIDER: S-EPMC4620310 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature