Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells.

ABSTRACT: During infection, naïve CD4(+) T helper cells differentiate into specialized effector subsets based upon environmental signals propagated by the cytokine milieu. Recently, this paradigm has been complicated by the demonstration that alterations in the cytokine environment can result in varying degrees of plasticity between effector T helper cell populations. Therefore, elucidation of the mechanisms by which cytokines regulate T helper cell differentiation decisions is increasingly important. The gamma common cytokine IL-15 is currently undergoing clinical trials for the treatment of malignancies, due to its well-established role in the regulation of natural killer and CD8(+) T cell immune responses. However, the effect of IL-15 signaling on CD4(+) T cell activity is incompletely understood

SUBMITTER: Cooley ID 

PROVIDER: S-EPMC4620557 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature