Long-term exposure to circulating platinum is associated with late effects of treatment in testicular cancer survivors.

ABSTRACT:

Background

The success of cisplatin-based (Platinol, Bristol-Myers Squibb Company, New York, NY, USA) chemotherapy for testicular cancer comes at the price of long-term and late effects related to healthy tissue damage. We assessed and modelled serum platinum (Pt) decay after chemotherapy and determined relationships between long-term circulating Pt levels and known late effects.

Patients and methods

In 99 testicular cancer survivors, treated with cisplatin-based chemotherapy, serum and 24-h urine samples were collected during follow-up (1-13 years after treatment). To build a population pharmacokinetic model, measured Pt data were simultaneously analysed, together with cisplatin dose, age, weight and height using the NONMEM software. Based on this model, area under the curv

SUBMITTER: Boer H 

PROVIDER: S-EPMC4621032 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature