Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study.

ABSTRACT:

Objectives

Myostatin (MSTN), a member of TGF-β superfamily, is produced in the skeletal muscle to inhibit myocyte differentiation. MSTN expression is increased in the skeletal muscle in patients with chronic kidney disease (CKD), which may play a role in the pathogenesis of sarcopenia or in the protein energy wasting (PEW). This observation implies that the plasma MSTN level may be correlated with kidney function. Thus, we conducted a cross-sectional study to evaluate the association between the plasma MSTN concentration and the estimated glomerular filtration rate (eGFR).

Subjects and methods

Subjects were 781 participants of a health examination performed in a rural area in Japan. Among them, 124 subjects were selected by stratified random sampling according to eGFR. Creat

SUBMITTER: Yano S 

PROVIDER: S-EPMC4621051 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature