Genetic associations of periodic limb movements of sleep in the elderly for the MrOS sleep study.

ABSTRACT:

Objective

The objective of this study was to assess the relationship between single-nucleotide polymorphisms associated with restless legs syndrome and periodic limb movements of sleep in a population cohort of elderly individuals.

Methods

Single-nucleotide polymorphisms previously associated with periodic limb movements of sleep or restless legs syndrome were analyzed in 2356 white male participants in the Osteoporotic Fractures in Men Sleep Study cohort. The associations between single-nucleotide polymorphisms and polysomnographically measured periodic limb movement index ≥15 were examined with logistic regression adjusted for age, ancestry markers, and periodic limb movements of sleep risk factors.

Results

Of the men in this cohort, 61% had a periodic limb movement

SUBMITTER: Winkelman JW 

PROVIDER: S-EPMC4621485 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature