Sleep interruption associated with house staff work schedules alters circadian gene expression.

ABSTRACT:

Background

Epidemiological studies indicate that disruption of circadian rhythm by shift work increases the risk of breast and prostate cancer. Our studies demonstrated that carcinogens disrupt the circadian expression of circadian genes (CGs) and circadian-controlled genes (CCGs) during the early stages of rat mammary carcinogenesis. A chemopreventive regimen of methylselenocysteine (MSC) restored the circadian expression of CGs and CCGs, including PERIOD 2 (PER2) and estrogen receptor β (ERS2), to normal. The present study evaluated whether changes in CG and CCG expression in whole blood can serve as indicators of circadian disruption in shift workers.

Methods

Fifteen shift workers were recruited to a crossover study. Blood samples were drawn before (6 PM) and after (8 AM)

SUBMITTER: Fang MZ 

PROVIDER: S-EPMC4621493 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature