Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent.

ABSTRACT: We previously demonstrated that prodynorphin (PDYN) haplotypes and single nucleotide polymorphism (SNP) rs2281285 are associated with alcohol dependence and the propensity to drink in negative emotional states, and recent studies suggest that PDYN gene effects on substance dependence risk may be sex-related. We examined sex-dependent associations of PDYN variation with alcohol dependence and related phenotypes, including negative craving, time until relapse after treatment and the length of sobriety episodes before seeking treatment, in discovery and validation cohorts of European ancestry. We found a significant haplotype-by-sex interaction (p  =  0.03), suggesting association with alcohol dependence in males (p = 1E-4) but not females. The rs2281285 G allele increased risk for alcohol de

SUBMITTER: Winham SJ 

PROVIDER: S-EPMC4621530 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature