A selective tropism of transfused oval cells for liver.

ABSTRACT: AIM:To explore the biological behaviors of hepatic oval cells after transfused into the circulation of experimental animals. METHODS:Oval cells from male SD rat were transfused into the circulation of a female rat which were treated by a 2-AAF/CCl(4) program, through caudal vein. Sex-determining gene sry which located on Y chromosome was examined by PCR and in situ hybridization technique in liver, kidney and spleen of the experimental animals, respectively. RESULTS:The results of the cell-transplant experiment showed that the sry gene was detectable only in the liver but not in spleen and kidney of the experimental rats, and no signals could be detected in the control animals. It can be also morphologically proved that some exogenous cells had migrated into the parenchyma of the liver and

SUBMITTER: Chen JZ 

PROVIDER: S-EPMC4621579 | biostudies-literature | 2003 Mar

REPOSITORIES: biostudies-literature