Emergent stem cell homeostasis in the C. elegans germline is revealed by hybrid modeling.

ABSTRACT: The establishment of homeostasis among cell growth, differentiation, and apoptosis is of key importance for organogenesis. Stem cells respond to temporally and spatially regulated signals by switching from mitotic proliferation to asymmetric cell division and differentiation. Executable computer models of signaling pathways can accurately reproduce a wide range of biological phenomena by reducing detailed chemical kinetics to a discrete, finite form. Moreover, coordinated cell movements and physical cell-cell interactions are required for the formation of three-dimensional structures that are the building blocks of organs. To capture all these aspects, we have developed a hybrid executable/physical model describing stem cell proliferation, differentiation, and homeostasis in the Caenorhabd

SUBMITTER: Hall BA 

PROVIDER: S-EPMC4621618 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature