Ontology highlight
ABSTRACT:
SUBMITTER: Kubinak JL
PROVIDER: S-EPMC4621775 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nature communications 20151023
The presentation of protein antigens on the cell surface by major histocompatibility complex (MHC) molecules coordinates vertebrate adaptive immune responses, thereby mediating susceptibility to a variety of autoimmune and infectious diseases. The composition of symbiotic microbial communities (the microbiota) is influenced by host immunity and can have a profound impact on host physiology. Here we use an MHC congenic mouse model to test the hypothesis that genetic variation at MHC genes among i ...[more]