Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias.

ABSTRACT:

Background

Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous, somewhat unpredictable diseases characterized by progressive scarring of the interstitium. Since lung function is a key determinant of survival, we reasoned that the transcriptional profile in IIP lung tissue would be associated with measures of lung function, and could enhance prognostic approaches to IIPs.

Results

Using gene expression profiling of 167 lung tissue specimens with IIP diagnosis and 50 control lungs, we identified genes whose expression is associated with changes in lung function (% predicted FVC and % predicted DLCO) modeled as categorical (severe vs mild disease) or continuous variables while adjusting for smoking status and IIP subtype; false discovery rate (FDR) approach wa

SUBMITTER: Steele MP 

PROVIDER: S-EPMC4621862 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature