DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer.

ABSTRACT:

Background

Conflicting results regarding the role of DEAD-box polypeptide 3 (DDX3) are seen not only between cancer types but also within the same type of cancer. In this study, we aimed at clarifying the prognostic significance of DDX3 in patients of major cancer types through large cohort survival analysis and further investigated its effects on cancer progression.

Methods

Large cohort survival analysis of 7 cancer types, including colorectal cancer, breast cancer, lung cancer, head and neck cancer, liver cancer, glioblastoma, and ovarian cancer, was performed using public database at RNA level and was further confirmed by IHC analysis at protein level. Phenotype parameters of DDX3 knockdown colon cancer cells and the mechanism of DDX3 regulated cancer progression were inv

SUBMITTER: Su CY 

PROVIDER: S-EPMC4621913 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature