Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status.

ABSTRACT: Osteosarcoma is the most common primary malignant bone tumor in children. Validated biological markers for disease prognosis available at diagnosis are lacking. No genome-wide DNA methylation studies linked to clinical outcomes have been reported in osteosarcoma to the best of our knowledge. To address this, we tested the methylome at over 1.1 million loci in 15 osteosarcoma biopsy samples obtained prior to the initiation of therapy and correlated these molecular data with disease outcomes. At more than 17% of the tested loci, samples obtained from patients who experienced disease relapse were more methylated than those from patients who did not have recurrence while patients who did not experience disease relapse had more DNA methylation at fewer than 1%. In samples from patients who went

SUBMITTER: Rosenblum JM 

PROVIDER: S-EPMC4622015 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature