Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography.

ABSTRACT: Probing the mechanical properties of tissue on the microscale could aid in the identification of diseased tissues that are inadequately detected using palpation or current clinical imaging modalities, with potential to guide medical procedures such as the excision of breast tumours. Compression optical coherence elastography (OCE) maps tissue strain with microscale spatial resolution and can delineate microstructural features within breast tissues. However, without a measure of the locally applied stress, strain provides only a qualitative indication of mechanical properties. To overcome this limitation, we present quantitative micro-elastography, which combines compression OCE with a compliant stress sensor to image tissue elasticity. The sensor consists of a layer of translucent silicone

SUBMITTER: Kennedy KM 

PROVIDER: S-EPMC4622092 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature