Metabolic status and resistin in chronic schizophrenia over a 2-year period with continuous atypical antipsychotics.

ABSTRACT:

Background

Common adverse effects of atypical antipsychotic treatments for schizophrenia are weight gain and lipid metabolism abnormality. We aimed to identify the signs of metabolic problems with continuous atypical antipsychotic treatment for schizophrenia over a 2-year period.

Methods

The participants were 68 schizophrenic patients (29 males, 39 females; ages 53.4 ± 13.5 years old). Changes in carbohydrate metabolism and changes in physical characteristics were studied over a 2-year period. In addition, functional single nucleotide polymorphisms in the transcriptional regulatory region of the resistin gene were examined.

Results

We found no changes in the mental state of the participants over a 2-year period. Patients did show a significant decrease in total choles

SUBMITTER: Kawabe K 

PROVIDER: S-EPMC4622120 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature