Molecular and Cellular Characteristics of the Colonic Pseudo-obstruction in Patients With Intractable Constipation.

ABSTRACT:

Background/aims

Chronic intestinal pseudo-obstruction (CIPO) is a disorder characterized by recurrent symptoms suggestive of obstruction such as abdominal pain, proximal distension with extremely suppressed motility in the absence of lumen-occluding lesion, whose etiology/ pathophysiology is poorly understood. In this study we investigated a functionally obstructive lesion that could underlie symptoms of CIPO.

Methods

We studied colons surgically removed from 13 patients exhibiting clinical/pathological features of pseudo-obstruction but were unresponsive to standard medical treatments. The colons were characterized morphologically, functionally and molecularly, which were compared between regions and to 28 region-matched controls obtained from colon cancer patients.

Resu

SUBMITTER: Do YS 

PROVIDER: S-EPMC4622139 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature