Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae.

ABSTRACT: Streptococcus pneumoniae is common nasopharyngeal commensal bacterium and important human pathogen. Vaccines against a subset of pneumococcal antigenic diversity have reduced rates of disease, without changing the frequency of asymptomatic carriage, through altering the bacterial population structure. These changes can be studied in detail through using genome sequencing to characterise systematically-sampled collections of carried S. pneumoniae. This dataset consists of 616 annotated draft genomes of isolates collected from children during routine visits to primary care physicians in Massachusetts between 2001, shortly after the seven valent polysaccharide conjugate vaccine was introduced, and 2007. Also made available are a core genome alignment and phylogeny describing the overall popul

SUBMITTER: Croucher NJ 

PROVIDER: S-EPMC4622223 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature