Generation of Self-Renewing Hepatoblasts From Human Embryonic Stem Cells by Chemical Approaches.

ABSTRACT:

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Somatic stem cells play crucial roles in organogenesis and tissue homeostasis and regeneration and may ultimately prove useful for cell therapy for a variety of degenerative diseases and injuries; however, isolation and expansion of most types of somatic stem cells from tissues are technically challenging. Human pluripotent stem cells are a renewable source for any adult cell types, including somatic stem cells. Generation of somatic stem cells from human pluripotent stem cells is a promising strategy to get these therapeutically valuable cells. Previously, we developed a chemically defined condition for mouse hepatoblast self-renewal through a reiterative screening strategy. In the present study, we efficiently generated hepatoblasts from human embryonic stem cells by a

SUBMITTER: Zhang M 

PROVIDER: S-EPMC4622408 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature