Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes.

ABSTRACT: Although age-associated gene expression and methylation changes have been reported throughout the literature, the unifying epigenomic principles of aging remain poorly understood. Recent explosion in availability and resolution of functional/regulatory genome annotation data (epigenomic data), such as that provided by the ENCODE and Roadmap Epigenomics projects, provides an opportunity for the identification of epigenomic mechanisms potentially altered by age-associated differentially methylated regions (aDMRs) and regulatory signatures in the promoters of age-associated genes (aGENs). In this study we found that aDMRs and aGENs identified in multiple independent studies share a common Polycomb Repressive Complex 2 signature marked by EZH2, SUZ12, CTCF binding sites, repressive H3K27me3, a

SUBMITTER: Dozmorov MG 

PROVIDER: S-EPMC4623031 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature