Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection.

ABSTRACT: Therapeutic antibodies represent one of the fastest growing segments in the pharmaceutical market. They are used in a broad range of disease fields, such as autoimmune diseases, cancer, inflammation and infectious diseases. The growth of the segment has necessitated development of new analytical platforms for faster and better antibody selection and characterization. Early quality control and risk assessment of biophysical parameters help prevent failure in later stages of antibody development, and thus can reduce costs and save time. Critical parameters such as aggregation, conformational stability, colloidal stability and hydrophilicity, are measured during the early phase of antibody generation and guide the selection process of the best lead candidates in terms of technical developabil

SUBMITTER: Lavoisier A 

PROVIDER: S-EPMC4623059 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature