Subconductance gating and voltage sensitivity of sarcoplasmic reticulum K(+) channels: a modeling approach.

ABSTRACT: Sarcoplasmic reticulum (SR) K(+) channels are voltage-regulated channels that are thought to be actively gating when the membrane potential across the SR is close to zero as is expected physiologically. A characteristic of SR K(+) channels is that they gate to subconductance open states but the relevance of the subconductance events and their contribution to the overall current flowing through the channels at physiological membrane potentials is not known. We have investigated the relationship between subconductance and full conductance openings and developed kinetic models to describe the voltage sensitivity of channel gating. Because there may be two subtypes of SR K(+) channels (TRIC-A and TRIC-B) present in most tissues, to conduct our study on a homogeneous population of SR K(+) chann

SUBMITTER: Matyjaszkiewicz A 

PROVIDER: S-EPMC4623209 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature