The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia.

ABSTRACT: PURPOSE:The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD). METHODS:The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA). Infants in the case group were given Montelukast sodium (Singulair) based on their body weight (BW). Zero week was defined as the start time of the study. RESULTS:The incidence of moderate to severe BPD was not different between the groups (case group: 13 of 30 [43.3%] vs. control group: 19 of 36 [52.8%], P=0.912). Additionally, secondary outcomes such as ventilation

SUBMITTER: Kim SB 

PROVIDER: S-EPMC4623454 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature