Design and Implementation of the International Genetics and Translational Research in Transplantation Network.

ABSTRACT:

Background

Genetic association studies of transplantation outcomes have been hampered by small samples and highly complex multifactorial phenotypes, hindering investigations of the genetic architecture of a range of comorbidities which significantly impact graft and recipient life expectancy. We describe here the rationale and design of the International Genetics & Translational Research in Transplantation Network. The network comprises 22 studies to date, including 16494 transplant recipients and 11669 donors, of whom more than 5000 are of non-European ancestry, all of whom have existing genomewide genotype data sets.

Methods

We describe the rich genetic and phenotypic information available in this consortium comprising heart, kidney, liver, and lung transplant cohorts.

SUBMITTER: International Genetics & Translational Research in Transplantation Network (iGeneTRAiN) 

PROVIDER: S-EPMC4623847 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature