A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity.

ABSTRACT: Water-soluble corroles with inherent fluorescence can form stable self-assemblies with tumor-targeted cell penetration proteins, and have been explored as agents for optical imaging and photosensitization of tumors in pre-clinical studies. However, the limited tissue-depth of excitation wavelengths limits their clinical applicability. To examine their utility in more clinically-relevant imaging and therapeutic modalities, here we have explored the use of corroles as contrast enhancing agents for magnetic resonance imaging (MRI), and evaluated their potential for tumor-selective delivery when encapsulated by a tumor-targeted polypeptide. We have found that a manganese-metallated corrole exhibits significant T1 relaxation shortening and MRI contrast enhancement that is blocked by particle fo

SUBMITTER: Sims JD 

PROVIDER: S-EPMC4623877 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature